18yrs initially one sinemet 25-100 tab 3 times daily or one sinemet 10-100 tab 3 4 times daily; increase every 1 2 days up to 2 tabs of either 25-100 or 10-100 tabs 4 times daily.

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Because both therapeutic and adverse responses occur more rapidly with SINEMET than with levodopa alonepatients should be monitored closely during the dose adjustment periodSpecificallyinvoluntary movements will occur more rapidly with SINEMET than with levodopaThe occurrence of involuntary movements may Fotos de nanda costa na revista trip require dosage reductionBlepharospasm may be a useful early sign of excess dosage in some patients.

Since its decarboxylase inhibiting activity is limited to extracerebral tissuesadministration of carbidopa with levodopa makes more levodopa available for transport to the brain.

None of the SINEMET tablets contain lactoseglutensucrosetartrazine or any other azo dyes.

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